BizTalk: Loading this assembly would produce a different grant set from other instances. (Exception from HRESULT: 0x80131401)

Hi BizTalk Buddies,

Hope you are all doing great. Time for another Article.

As we all know that the BizTalk host can either be 32-bit or 64-bit and our host instances run on those hosts. 

As we might also know, 
Running the FTP adapter, POP3 adapter, and MIME Decoder on 64-bit host instances is not supported. We can only run them on 32-bit host instances.

Errors in the event viewer:-
There was a failure executing the send pipeline: "Microsoft.BizTalk.DefaultPipelines.XMLTransmit, Microsoft.BizTalk.DefaultPipelines, Version=3.0.1.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35" Source: "XML assembler" Send Port: "sendPortName" URI: "mssql://xxxxServerName//xxxxDBName?" Reason: Loading this assembly would produce a different grant set from other instances. (Exception from HRESULT: 0x80131401)


A message sent to adapter "WCF-SQL" on send port "sendPortName" with URI "mssql://xxxxServerName//xxxxDBName?" is suspended. 
 Error details: There was a failure executing the send pipeline: "Microsoft.BizTalk.DefaultPipelines.XMLTransmit, Microsoft.BizTalk.DefaultPipelines, Version=3.0.1.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35" Source: "XML assembler" Send Port: "xxxYourSendPortName" URI: "mssql://ltvmanchikanti//Insurance_Collections?" Reason: Loading this assembly would produce a different grant set from other instances. (Exception from HRESULT: 0x80131401)  
 MessageId:  {934486D4-5F64-4EED-BBE8-E68A5F5DDBA8}
 InstanceID: {C78702BB-4DFE-412B-98F9-AAD347660ACC}


There was a failure executing the response(receive) pipeline: "Microsoft.BizTalk.DefaultPipelines.XMLReceive, Microsoft.BizTalk.DefaultPipelines, Version=3.0.1.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35" Source: "XML disassembler" Send Port: "xxxYourSendPortName" URI: "mssql://xxxxServerName//xxxxDBName?" Reason: Loading this assembly would produce a different grant set from other instances. (Exception from HRESULT: 0x80131401)

Reason:- The reason why we are getting the above errors is that our send adapter hander on the port where we get an error is running on a 32-bit host as opposed to 64-bit.

NB: Normally this happens when we use default host(BizTalkServerApplication which might be a 32-bit host) that gets created when BizTalk is installed.

Solution Steps:- 

• We must create the host with 32-bit only checkbox un-checked as shown below.

• Create the send/receive handler on the Adapter(in my Case WCF-SQL but the principle is same for other adapters that run on the 64-bit host) that we have experienceing the issue on.

• Select the adapter handler that is created in the above step as shown below.